Virtual screening, oriented-Synthesis and evaluation of lipase inhibitory activity of benzyl amino chalcone derivatives

and rutin was contributed to the inhibitory activity [27, 28]. The strongly lipase inhibitory effect may be attributable to the synergetic effect of different chaicones in the extract. Moreover, it was possible to enhance the inhibitory activity of flavone by attaching a group of C-glucoside. The research group also confirmed that C-glycosyl flavones with two sugar moieties at C6 showed the highest inhibitory effect [7] , In addition, the existence of galloyl moieties within the structure of flavan-3-ols is responsible for the increase of HPL inhibition [29]. The results showed that benzyl amino chaicone derivatives