Staphylococcus aureus nasal colonization among Vietnamese adults

Antibiotic susceptibility profile of S', aureus nasal isolates Ill tills study, resistant rate of s. aureus isolates were found to be 95.7% for ampicillin, 34.8% for cephalexin, erythromycin, kanamycin, and clindamycin, 47.8% for mcropcncm, 17.4% for tetracycline, 21.7% for ciprofloxacin and 4.3% for linezolid. Especially, vancomycin continued to be the treatment of choice for heating most MRSA infections with none of isolates (0%) resistant to tins agent. The data was summarized 111 Figure 1. The prevalence of multi-drug resistance (resistant to at least 3 tested antibiotics) of s. aureus isolates was shown 111 Figure 2. There were thirteen isolates with resistance to at least 3 antibiotics of which two isolates were identified to be resistant to 8 antibiotics. Only one isolate was susceptible to all antimicrobial agents. With the high resistance rate, ampicillin, meropenem and even cephalexin, clindamycin, erythromycin and kanamycin were not suggested for s. aureus infections treatment. It is different to recent study showing that first generation cephalosporins (cefazolin, cephalothin and cephalexin), clindamycin and erythromycin have important therapeutic roles in less serious s. aureus infections such as skin and soft tissue infections or in patients with penicillin hypersensitivity (urticaria, angioedema, bronchospasm or anaphylaxis) [15]. Besides, in our study, ciprofloxacin and tetracycline are two antibiotics to which s. aureus has low resistant rate (21.7% and 17.4%, respectively). Our results also suggested that hnezohd and vancomycin remain important in the treatment of s. aureus infections because of high susceptible rate- 95.7% and 100%, respectively. It is in agreement xvith previous results showing that vancomycin has been considered the treatment of choice for infection due to s. aureus [16].